Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism


Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue repair remains unexplained. Lin28a, a highly conserved RNA-binding protein expressed during embryogenesis, plays roles in development, pluripotency, and metabolism. To determine whether Lin28a might influence tissue repair in adults, we engineered the reactivation of… (More)
DOI: 10.1016/j.cell.2013.09.059