Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.

@article{Chang2009Lin28BTI,
  title={Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.},
  author={Tsung-Cheng Chang and Lauren R. Zeitels and Hun-Way Hwang and Raghu R. Chivukula and Erik A. Wentzel and Michael Dews and Jason Jung and Ping Gao and Chi V. Dang and Michael A. Beer and Andrei Thomas-Tikhonenko and Joshua T. Mendell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 9},
  pages={3384-9}
}
Direct control of microRNA (miRNA) expression by oncogenic and tumor suppressor networks results in frequent dysregulation of miRNAs in cancer cells and contributes to tumorigenesis. We previously demonstrated that activation of the c-Myc oncogenic transcription factor (Myc) broadly influences miRNA expression and in particular leads to widespread miRNA down-regulation. miRNA transcripts repressed by Myc include several with potent tumor suppressor activity such as miR-15a/16-1, miR-34a, and… CONTINUE READING
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Suppression of non-small cell lung tumor development by the let-7 microRNA family.

Proceedings of the National Academy of Sciences of the United States of America • 2008

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