Limonene, a natural cyclic terpene, is an agonistic ligand for adenosine A(2A) receptors.

  title={Limonene, a natural cyclic terpene, is an agonistic ligand for adenosine A(2A) receptors.},
  author={Hyo Min Park and Ji Hae Lee and Jia Yaoyao and Hee Jin Jun and Sung Joon Lee},
  journal={Biochemical and biophysical research communications},
  volume={404 1},
Limonene is a major aromatic compound in essential oils extracted from citrus rind. The application of limonene, especially in aromatherapy, has expanded significantly, but its potential effects on cellular metabolism have been elusive. We found that limonene directly binds to the adenosine A(2A) receptor, which may induce sedative effects. Results from an in vitro radioligand binding assay showed that limonene exhibits selective affinity to A(2A) receptors. In addition, limonene increased… CONTINUE READING
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