Limits of 8-Tesla magnetic resonance imaging spatial resolution of the deoxygenated cerebral microvasculature.

Abstract

PURPOSE To quantify the minimum magnetic resonance imaging (MRI) spatial resolution of the visible deoxygenated microscopic vessels of the human brain at 8 T. MATERIALS AND METHODS This study compared 8-T gradient echo (GE) images of a human cadaver brain having an in-plane resolution of 195 x 195 microm to corresponding digital photographs of 205 cryomicrotome sections of the same cadaver brain, along with summed images of 25 contiguous cryomicrotome sections. One-millimeter-thick GE images of a 1-cm-thick unfixed whole coronal brain section were acquired using techniques similar to those commonly utilized for 8-T human imaging in vivo. RESULTS There was excellent MR visualization of the deoxygenated microscopic vessels within the brain down to a resolution of approximately 100 microm. CONCLUSION By taking advantage of magnetic susceptibility-based blood oxygenation level-dependent (BOLD) contrast, deoxygenated microscopic blood vessels smaller than the pixel dimensions used for imaging can be visualized using a whole-body 8-T MRI system.

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@article{Dashner2004LimitsO8, title={Limits of 8-Tesla magnetic resonance imaging spatial resolution of the deoxygenated cerebral microvasculature.}, author={Roger A Dashner and Allahyar Kangarlu and David L . Clark and Abhik Raychaudhury and Donald william Chakeres}, journal={Journal of magnetic resonance imaging : JMRI}, year={2004}, volume={19 3}, pages={303-7} }