Limiting glucocorticoid secretion increases the anorexigenic property of Exendin-4

  title={Limiting glucocorticoid secretion increases the anorexigenic property of Exendin-4},
  author={Shin Jae Lee and Katharina Diener and Sharon Kaufman and Jean-Philippe Krieger and Klaus Grossi Pettersen and Nino Jejelava and Myrtha M Arnold and Alan G. Watts and Wolfgang Langhans},
  booktitle={Molecular metabolism},
OBJECTIVE Glucagon-like peptide-1 (GLP-1) analogs are attractive options for the treatment of type II diabetes and obesity because of their incretin and anorexigenic effects. Peripheral administration of the GLP-1R agonist Exendin-4 (Ex-4) also increases glucocorticoid secretion in rodents and humans, but whether the released glucocorticoids interact with Ex-4's anorexigenic effect remains unclear. METHODS To test this, we used two experimental approaches that suppress corticosterone… CONTINUE READING
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