Limiting factors for maximum oxygen uptake and determinants of endurance performance.

@article{Bassett2000LimitingFF,
  title={Limiting factors for maximum oxygen uptake and determinants of endurance performance.},
  author={David Bassett and Edward T. Howley},
  journal={Medicine and science in sports and exercise},
  year={2000},
  volume={32 1},
  pages={
          70-84
        }
}
In the exercising human, maximal oxygen uptake (VO2max) is limited by the ability of the cardiorespiratory system to deliver oxygen to the exercising muscles. This is shown by three major lines of evidence: 1) when oxygen delivery is altered (by blood doping, hypoxia, or beta-blockade), VO2max changes accordingly; 2) the increase in VO2max with training results primarily from an increase in maximal cardiac output (not an increase in the a-v O2 difference); and 3) when a small muscle mass is… 

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