Limiting concentrations of activated mononucleotides necessary for poly(C)-directed elongation of oligoguanylates

@article{Kanavarioti2005LimitingCO,
  title={Limiting concentrations of activated mononucleotides necessary for poly(C)-directed elongation of oligoguanylates},
  author={A. Kanavarioti and S. Chang and D. Alberas},
  journal={Journal of Molecular Evolution},
  year={2005},
  volume={31},
  pages={462-469}
}
SummarySelected imidazolide-activated nucleotides have been subjected to hydrolysis under conditions similar to those that favor their template-directed oligomerization. Rate constants of hydrolysis of the P−N bond in guanosine 5′-monophosphate 2-methylimidazolide (2-MeImpG) and in guanosine 5′-monophosphate imidazolide (ImpG), kh, have been determined in the presence/absence of magnesium ion as a function of temperature and polycytidylate [poly(C)] concentration. Using the rate constant of… Expand
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