Limiting TCR expression leads to quantitative but not qualitative changes in thymic selection.

@article{Dave1999LimitingTE,
  title={Limiting TCR expression leads to quantitative but not qualitative changes in thymic selection.},
  author={Vibhuti P. Dave and David Allman and David L Wiest and Dietmar J. Kappes},
  journal={Journal of immunology},
  year={1999},
  volume={162 10},
  pages={
          5764-74
        }
}
Thymic selection is controlled in part by the avidity of the interaction between thymocytes and APCs. In agreement, the selective outcome can be modulated by altering the expression levels of selecting ligands on APCs. Here we test the converse proposition, i. e., whether changing TCR levels on thymocytes can alter the selective outcome. To this end, we have generated mice in which all thymocytes express two transgenic TCRs simultaneously (dual TCR-expressing (DTE) mice), the class I-restricted… CONTINUE READING

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