Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors

@article{Oritani2000LimitinAI,
  title={Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors},
  author={Kenji Oritani and Kay L Medina and Yoshiaki Tomiyama and Jun Ishikawa and Yuko Okajima and Megumu Ogawa and Takahumi Yokota and Keisuke Aoyama and Isao Takahashi and Paul W. Kincade and Yuji Matsuzawa},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={659-666}
}
We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho–hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon α/β receptors and induces interferon regulatory factor-1, it may represent a previously unknown type I interferon prototype. However, preferential B-lineage growth inhibition and… 
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128 Citations
Highly Influential Citations
2
Background Citations
37
Methods Citations
6
Results Citations
2

128 Citations

Limitin: an interferon-like cytokine without myeloerythroid suppressive properties
TLDR
Limitin binds to the IFN-α/β receptors and induces IFN regulatory factor-1, thereby indicating that limitin constitutes a new prototype of the type I IFN family and should play a role in the complex IFN network.
A New IFN-Like Cytokine, Limitin Modulates the Immune Response Without Influencing Thymocyte Development1
TLDR
It can be speculated that the human homolog of limitin may be applicable for clinical usage because of its IFN-like activities with low adverse effects on, for example, T lymphopoiesis, erythropoiesi, and myelopoiedis.
Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
The Type I Interferon System With Emphasis on Its Role in Malignancies
TLDR
This chapter will focus on the biology of IFN-α and its effects on downstream signaling events within the tumor cell and host immune effectors and both endogenous and exogenously administered IFNα2.
The Role of Activin A in Regulation of Hemopoiesis
TLDR
Whereas the functions of activin A in vitro are well established, further research tools are needed to elucidate its role within specific hemopoietic microenvironments in vivo.
Differential effects of a novel IFN-ζ/limitin and IFN-α on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes
PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON.
Antiviral Activity of Limitin against Encephalomyocarditis Virus, Herpes Simplex Virus, and Mouse Hepatitis Virus: Diverse Requirements by Limitin and Alpha Interferon for Interferon Regulatory Factor 1
TLDR
The unique signals and the fewer properties of myelosuppression suggest that a human homolog of limitin may be used as a new antiviral drug.
Interferon-κ, a Novel Type I Interferon Expressed in Human Keratinocytes*
TLDR
Interferon-κ therefore defines a novel subclass of type I interferon that is expressed in keratinocytes and expands the repertoire of known proteins mediating host defense.
Role of activin A in negative regulation of normal and tumor B lymphocytes
TLDR
Data points to a role of activin A in negative regulation of B lineage lymphocytes in the hematopoietic system, and the relative concentration of biologically functionalactivin A, in different parts of the tissue, may determine the local B cell content and functional state of thesecells within a specific microenvironment.
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References

SHOWING 1-10 OF 71 REFERENCES
Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells.
Negative regulation of early B lymphopoiesis by interleukin 3 and interleukin 1 alpha.
TLDR
It is reported that addition of IL-3 or IL-1 alpha to a permissive system suppresses the B-lymphoid potential of primitive progenitor cells in primary culture in dose-dependent fashion, suggesting negative regulatory roles for IL- 3 and IL- 1 alpha in early stages of B lymphopoiesis.
Indirect suppression of IL-7-responsive B cell precursors by vasoactive intestinal peptide.
TLDR
It is suggested that a neuropeptide can potentially modulate lymphopoiesis through a regulatory circuit that involves macrophages and IFN-alpha and the possibility that VIP can participate in antiviral defense.
A protein tyrosine kinase in the interferon α β signaling pathway
IL-1 inhibits B cell differentiation in long term bone marrow cultures.
TLDR
B lymphopoiesis was inhibited and myelopoiedis maintained upon addition of recombinant granulocyte-, macrophage-, and granulocytes-macrophage-CSF to cultures, indicating that IL-1 or other non- CSF molecules induced by it need not be present.
Suppression of B lymphopoiesis during normal pregnancy
TLDR
Pregnancy-related changes in bone marrow were selective for B lineage precursors, as cells expressing myeloid and erythroid markers were not reduced and production and export of lymphocytes from marrow may be substantially decreased.
Estrogen suppresses stromal cell-dependent lymphopoiesis in culture.
TLDR
It is found that estrogen receptor mRNA was detectable by RT-PCR in lymphocyte supporting stromal cells as well as B lymphocyte precursors, indicating that estrogen may regulate B lymphopoiesis via its influence on the microenvironment and that estrogen-inducedStromal cell genes merit further study.
Functional role of type I and type II interferons in antiviral defense.
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
TLDR
Two different anti-onco-genic transcription factors, p53 and IRF-1, are required for distinct apoptotic pathways in T lymphocytes, which shows that mitogen induction of the interleukin-lβ converting enzyme (ICE) gene8á¤-10, a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3, is IRf-1-dependent.
Characterization of β-R1, a Gene That Is Selectively Induced by Interferon β (IFN-β) Compared with IFN-α*
TLDR
Induction of the β-R1 gene in fibrosarcoma cells and derivative mutant cells lacking components required for signaling by type I IFNs requires IFN-stimulated gene factor 3 plus an additional component, which is more efficiently formed on induction by IFn-β compared withIFN-α.
...
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