Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors

@article{Oritani2000LimitinAI,
  title={Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors},
  author={Kenji Oritani and Kay L Medina and Yoshiaki Tomiyama and Jun Ishikawa and Yuko Okajima and Megumu Ogawa and Takahumi Yokota and Keisuke Aoyama and Isao Takahashi and Paul W. Kincade and Yuji Matsuzawa},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={659-666}
}
We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho–hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon α/β receptors and induces interferon regulatory factor-1, it may represent a previously unknown type I interferon prototype. However, preferential B-lineage growth inhibition and… 
Limitin: an interferon-like cytokine without myeloerythroid suppressive properties
TLDR
Limitin binds to the IFN-α/β receptors and induces IFN regulatory factor-1, thereby indicating that limitin constitutes a new prototype of the type I IFN family and should play a role in the complex IFN network.
A New IFN-Like Cytokine, Limitin Modulates the Immune Response Without Influencing Thymocyte Development1
TLDR
It can be speculated that the human homolog of limitin may be applicable for clinical usage because of its IFN-like activities with low adverse effects on, for example, T lymphopoiesis, erythropoiesi, and myelopoiedis.
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TLDR
The unique signals and the fewer properties of myelosuppression suggest that a human homolog of limitin may be used as a new antiviral drug.
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