Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells.

@article{Renne1998LimitedTO,
  title={Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells.},
  author={Rolf Renne and David J. Blackbourn and Denise Whitby and J. Levy and Donald E Ganem},
  journal={Journal of virology},
  year={1998},
  volume={72 6},
  pages={5182-8}
}
Kaposi's sarcoma-associated herpesvirus (KSHV) (also called human herpesvirus 8) is a novel gammaherpesvirus strongly implicated in the pathogenesis of Kaposi's sarcoma. Although virions can be produced in high yield from latently infected B-cell lines treated with phorbol esters, little is known about the infectivity of such virus, and efficient serial propagation of KSHV has been problematic. Here we report on the infectivity of KSHV produced from phorbol-induced BCBL-1 cells, employing an… CONTINUE READING

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