Limited tolerance towards folded elements during secretion of the autotransporter Hbp.

@article{Jong2007LimitedTT,
  title={Limited tolerance towards folded elements during secretion of the autotransporter Hbp.},
  author={Wouter S. P. Jong and Corinne M. ten Hagen-Jongman and Tanneke den Blaauwen and Dirk Jan Slotboom and Jeremy R. H. Tame and David Wickstr{\"o}m and Jan-Willem de Gier and Ben R. Otto and Joen Luirink},
  journal={Molecular microbiology},
  year={2007},
  volume={63 5},
  pages={
          1524-36
        }
}
Many virulence factors secreted by pathogenic Gram-negative bacteria belong to the autotransporter (AT) family. ATs consist of a passenger domain, which is the actual secreted moiety, and a beta-domain that facilitates the transfer of the passenger domain across the outer membrane. Here, we analysed folding and translocation of the AT passenger, using Escherichia coli haemoglobin protease (Hbp) as a model protein. Dual cysteine mutagenesis, instigated by the unique crystal structure of the Hbp… CONTINUE READING
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