Limited sampling strategy for the estimation of systemic exposure to the protease inhibitor nelfinavir.

@article{Regazzi2005LimitedSS,
  title={Limited sampling strategy for the estimation of systemic exposure to the protease inhibitor nelfinavir.},
  author={Mario B. Regazzi and Carmine Tinelli and Paola Villani and Maria Cusato and Patrizia Zucchi and Annalisa De Silvestri and Elena Briganti and Rinaldo Roda and Luca Sacchelli and Francesca Gatti and Palma Delle Foglie and Giulia Nardini and Fernanda Mori and P. Castelli and Lucia Testa and Renato Maserati},
  journal={Therapeutic drug monitoring},
  year={2005},
  volume={27 5},
  pages={571-5}
}
Therapeutic drug monitoring (TDM) of antiretroviral drugs has been proposed as a means of optimizing response to highly active antiretroviral therapy (HAART) in HIV infection because suboptimal exposure to these agents may lead to the development of resistant viral strains and subsequent therapeutic failure. The area under the curve (AUC), though considered to make the best estimate of total drug exposure, requires repeated blood sampling. The authors investigated the predictability of… CONTINUE READING
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