Limited sampling strategies for therapeutic drug monitoring of mycophenolate mofetil therapy in patients with autoimmune disease.

@article{Winter2009LimitedSS,
  title={Limited sampling strategies for therapeutic drug monitoring of mycophenolate mofetil therapy in patients with autoimmune disease.},
  author={Brenda C. M. de Winter and Irmgard Neumann and Reinier M. van Hest and Teun van Gelder and Ron A. A. Math{\^o}t},
  journal={Therapeutic drug monitoring},
  year={2009},
  volume={31 3},
  pages={382-90}
}
Mycophenolate mofetil (MMF) is increasingly used for the treatment of autoimmune diseases (AID). In renal transplant recipients, it has been demonstrated that adjustment of the MMF dose according to the area under the plasma concentration versus time curve (AUC) of mycophenolic acid (MPA), the active moiety of MMF, improves clinical outcome. The aim of this study was to develop a maximum a posteriori Bayesian estimator (MAP-BE) to estimate MPA AUC(0-12) in patients with AID using a limited… CONTINUE READING