Limited sampling models for doxorubicin pharmacokinetics.

  title={Limited sampling models for doxorubicin pharmacokinetics.},
  author={Mark J. Ratain and Jean - Robert and W J Van der vijgh},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={9 5},
Although doxorubicin is one of the most commonly used antineoplastics, no studies to date have clearly related the area under the concentration-time curve (AUC) to toxicity or response. The limited sampling model has recently been shown to be a feasible method for estimating the AUC to facilitate pharmacodynamic studies. Data from two previous studies of doxorubicin pharmacokinetics were used, including 26 patients with sarcoma and five patients with breast cancer or unknown primary. The former… CONTINUE READING
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