Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells.

@article{Loi2006LimitedRO,
  title={Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells.},
  author={Roberto Loi and Travis Beckett and Kaarin K. Goncz and Benjamin T Suratt and Daniel J. Weiss},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={173 2},
  pages={
          171-9
        }
}
RATIONALE Recent literature suggests that adult bone marrow-derived cells can localize to lung and acquire immunophenotypic characteristics of lung epithelial cells. We speculated this might be a potential therapeutic approach for correcting defective lung epithelium in cystic fibrosis. OBJECTIVE To determine whether adult bone marrow-derived cells containing normal cystic fibrosis transmembrane conductance regulator protein (CFTR) could repopulate lung epithelium in transgenic mice deficient… CONTINUE READING

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