Limited remyelination in Theiler's murine encephalomyelitis due to insufficient oligodendroglial differentiation of nerve/glial antigen 2 (NG2)-positive putative oligodendroglial progenitor cells.

@article{Ulrich2008LimitedRI,
  title={Limited remyelination in Theiler's murine encephalomyelitis due to insufficient oligodendroglial differentiation of nerve/glial antigen 2 (NG2)-positive putative oligodendroglial progenitor cells.},
  author={Reiner G. Ulrich and Frank Seeliger and Mihaela Kreutzer and P G Germann and Wolfgang Baumgaertner},
  journal={Neuropathology and applied neurobiology},
  year={2008},
  volume={34 6},
  pages={603-20}
}
AIMS Limited remyelination is a key feature of demyelinating Theiler's murine encephalomyelitis (TME). It is hypothesized that a dysregulation of differentiation of oligodendroglial progenitor cells (OPCs) represents the main cause of insufficient regeneration in this model of multiple sclerosis. METHODS TME virus (TMEV)-infected SJL/J mice were evaluated by footprint analysis, light and electron microscopy, immunohistology, confocal immunofluorescence and RT-qPCR at multiple time points… CONTINUE READING
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