Limited proteolysis of angiogenin by elastase is regulated by plasminogen.

@article{Hu1997LimitedPO,
  title={Limited proteolysis of angiogenin by elastase is regulated by plasminogen.},
  author={Guang Hu},
  journal={Journal of protein chemistry},
  year={1997},
  volume={16 7},
  pages={669-79}
}
  • Guang Hu
  • Published 1997 in Journal of protein chemistry
Human neutrophil elastase cleaves angiogenin at the Ile-29/Met-30 peptide bond to produce two major disulfide-linked fragments with apparent molecular weights of 10,000 and 4000, respectively. Elastase-cleaved angiogenin has slightly increased ribonucleolytic activity, but has lost its ability to undergo nuclear translocation in endothelial cells, a process essential for angiogenic activity. Cleavage appears to alter the cell-binding properties of angiogenin, despite the fact that it occurs… CONTINUE READING