Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization.

@article{Sloan2013LimitedNC,
  title={Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization.},
  author={Emily A Sloan and Mary F Kearney and Laurie R. Gray and Kathryn M Anastos and Eric S Daar and Joseph B. Margolick and Frank M Maldarelli and Marie-Louise Hammarskjold and David Rekosh},
  journal={Journal of virology},
  year={2013},
  volume={87 20},
  pages={11173-86}
}
HIV-1 Rev and the Rev response element (RRE) enable a critical step in the viral replication cycle by facilitating the nuclear export of intron-containing mRNAs, yet their activities have rarely been analyzed in natural infections. This study characterized their genetic and functional variation in a small cohort of HIV-infected individuals. Multiple Rev and RRE sequences were obtained using single-genome sequencing (SGS) of plasma samples collected within 6 months after seroconversion and at a… CONTINUE READING