Limited interleukin-18 response in Salmonella-infected murine macrophages and in Salmonella-infected mice.

@article{Elhofy1999LimitedIR,
  title={Limited interleukin-18 response in Salmonella-infected murine macrophages and in Salmonella-infected mice.},
  author={Adam Elhofy and Kenneth L. Bost},
  journal={Infection and immunity},
  year={1999},
  volume={67 10},
  pages={5021-6}
}
Optimal immune responses against an intracellular bacterial pathogen, such as Salmonella, involve the production of gamma interferon (IFN-gamma), which activates macrophages. It has recently been suggested that, interleukin-18 (IL-18), in addition to IL-12, contributes to the induction of IFN-gamma following infection. Given this hypothesis, an optimal host immune response against intracellular bacterial pathogens would include the induction of IL-18 secretion by macrophages due to Salmonella… CONTINUE READING

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