Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

Abstract

The extent of heterogeneity among driver gene mutations present in naturally occurring metastases—that is, treatment-naive metastatic disease—is largely unknown. To address this issue, we carried out 60× whole-genome sequencing of 26 metastases from four patients with pancreatic cancer. We found that identical mutations in known driver genes were present in… (More)
DOI: 10.1038/ng.3764

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