Limited heterogeneity of T cell receptor variable region gene usage in juvenile rheumatoid arthritis synovial T cells.

@article{Sioud1992LimitedHO,
  title={Limited heterogeneity of T cell receptor variable region gene usage in juvenile rheumatoid arthritis synovial T cells.},
  author={Mouldy Sioud and Jens Kjeldsen-Kragh and Sezer Fırat Suleyman and Odd Vinje and Jacob B. Natvig and Oystein T. F\orre},
  journal={European journal of immunology},
  year={1992},
  volume={22 9},
  pages={2413-8}
}
The aim of this study was to determine whether synovial fluid (SF) T cells in patients with juvenile rheumatoid arthritis (JRA) are restricted in their T cell receptor (TcR) gene repertoire. The quantitative polymerase chain reaction (QPCR) was used to compare the transcription of V beta and V alpha gene families in freshly isolated SF T cells, in interleukin-2 receptor-positive (IL-2R+) T cells and in peripheral blood (PB) T cells from 18 patients. Significantly less V beta families are… CONTINUE READING