Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates.

@article{Gruber2006LimitedGO,
  title={Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates.},
  author={Andr{\'a}s Gruber and Jos{\'e} Aneiros Fern{\'a}ndez and Leslie Bush and Ulla M. Marzec and John H. Griffin and Stephen R. Hanson and Enrico Di Cera},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2006},
  volume={4 2},
  pages={392-7}
}
Anticoagulation with activated protein C (APC) reduces the mortality of severe sepsis. We investigated whether the circulating protein C (PC) pool could be utilized for sustained anticoagulation by endogenous APC. To generate APC without procoagulant effects, we administered the anticoagulant thrombin mutant W215A;E217A (WE) to baboons. In preliminary… CONTINUE READING