Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine.

@article{Karpf2004LimitedGA,
  title={Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine.},
  author={Adam R. Karpf and Amy W Lasek and Ted O Ririe and Adrianne N. Hanks and Douglas Grossman and David A Jones},
  journal={Molecular pharmacology},
  year={2004},
  volume={65 1},
  pages={18-27}
}
It remains unclear to what extent drugs targeting transcriptional repressor complexes affect global gene expression in cells derived from target and nontarget human tissues. To address this question, we used genome-wide expression analysis using microarrays to analyze the response of three tumor and one normal epithelial cell line to treatment with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR). Notably, we found that 5-aza-CdR treatment induced a limited number of genes… CONTINUE READING