Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium.

@article{Smyth2010LimitedFT,
  title={Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium.},
  author={James W P Smyth and T. Hong and Danchen Gao and Jacob M. Vogan and Brian C Jensen and Tina S. Fong and Paul C. Simpson and Didier Y. R. Stainier and Neil C Chi and Robin Shaw},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 1},
  pages={266-79}
}
Gap junctions form electrical conduits between adjacent myocardial cells, permitting rapid spatial passage of the excitation current essential to each heartbeat. Arrhythmogenic decreases in gap junction coupling are a characteristic of stressed, failing, and aging myocardium, but the mechanisms of decreased coupling are poorly understood. We previously found that microtubules bearing gap junction hemichannels (connexons) can deliver their cargo directly to adherens junctions. The specificity of… CONTINUE READING

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