Limited expression of C/EBP family proteins during B lymphocyte development. Negative regulator Ig/EBP predominates early and activator NF-IL-6 is induced later.

@article{Cooper1994LimitedEO,
  title={Limited expression of C/EBP family proteins during B lymphocyte development. Negative regulator Ig/EBP predominates early and activator NF-IL-6 is induced later.},
  author={Charles L. Cooper and Allison L. Berrier and Christopher Roman and Kathryn L. Calame},
  journal={Journal of immunology},
  year={1994},
  volume={153 11},
  pages={
          5049-58
        }
}
The importance of C/EBP proteins in B cell biology is suggested by the occurrence of functionally important C/EBP binding sites in Ig gene enhancers and promoters, and the knowledge that family member NF-IL-6 is induced in other systems in response to regulators of B cell differentiation. We have studied the expression pattern and activity of C/EBP family transcriptional regulators in B cells at different developmental stages by using B cell lines and normal splenic B cells. Two family members… CONTINUE READING
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