Limited efficacy of an inactivated feline immunodeficiency virus vaccine

  title={Limited efficacy of an inactivated feline immunodeficiency virus vaccine},
  author={Stephen Dunham and Jennifer Bruce and S Mackay and M C Golder and Oswald Jarrett and James C Neil},
  journal={Veterinary Record},
  pages={561 - 562}
FELINE immunodeficiency virus (FIV) is a widespread pathogen of domestic cats associated with a variety of clinical signs, including gingivitis, stomatitis and recurrent infections (Hosie and others 1989). FIV, like human immunodeficiency virus, is a lentivirus of the family Retroviridae. Isolates of FIV are genetically diverse and are classified into subtypes, designated A, B, C, D and E, based on their nucleotide sequence. The prevalence of these subtypes differs throughout the world; for… 
Phylogenetic analysis to define feline immunodeficiency virus subtypes in 31 domestic cats in South Africa.
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Feline immunodeficiency virus model for designing HIV/AIDS vaccines.
Findings from these studies are being used to define the prophylactic epitopes needed for an HIV-1 vaccine for humans.
The Comparative Value of Feline Virology Research: Can Findings from the Feline Lentiviral Vaccine Be Translated to Humans?
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It is important that the key determinants of immunity induced by this vaccine are discovered; such data would compliment vaccine field efficacy studies and provide the basis to make informed recommendations on its use.
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A robust and reproducible in vitro neutralisation assay was developed and optimised, permitting the assessment of the NAb response in naturally infected cats and with the potential to evaluate candidate vaccines, and it was demonstrated that, in general, primary FIV strains in the UK belong to subtype A, and therefore the development of a regional, sub type A-specific, FIV vaccine could be considered for use in the US.
Feline immunodeficiency. ABCD guidelines on prevention and management
Virus evolution in the progression of natural feline immunodeficiency virus infection
It was shown that sick cats were more likely to harbour viruses of the “late” phenotype than healthy animals, similar to the co-receptor switch observed during the progression of HIV infection, which broadens the understanding of natural FIV infection.
FIV vaccine development: a continuing challenge
Although FIV is phylogenetically more distant from HIV-1 than the primate lentiviruses it shares many structural and biochemical characteristics with HIV and given the close resemblance of the pathogeneses of infections with both viruses in their respective hosts, FIV infection of the cat has established itself as an excellent small animal model for lentiviral infections in general and lentivirus vaccine development in particular.


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Findings suggested that a new circulating recombinant FIV may be enzootic in Ontario, with evidence of co-infection with parental strains of subtypes A and B as indicated by PCR-based limiting dilution assays.
Immunogenicity of an Anti-Clade B Feline Immunodeficiency Fixed-Cell Virus Vaccine in Field Cats
The data suggest that a fixed, FIV-infected cell vaccine has potential for preventing natural FIV infection in free-roaming cats.
Phylogenetic analysis of feline immunodeficiency virus in Central Europe: a prerequisite for vaccination and molecular diagnostics.
A phylogenetic analysis of 30 FIV strains derived from Central Europe points to the existence of extensive virus variation with the presence of at least two highly divergent subtypes of FIV in Austria and Germany.
Vaccination with Inactivated Virus but Not Viral DNA Reduces Virus Load following Challenge with a Heterologous and Virulent Isolate of Feline Immunodeficiency Virus
Results indicate that the more virulent FIVGL8 is intrinsically more resistant to vaccinal immunity than the FIVPET strain and that a broad spectrum of responses which includes virus neutralizing antibodies is a desirable goal for lentivirus vaccine development.
Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom
It was concluded that both viruses were significant causes of disease, and that the cats most likely to be infected with FIV were older, free-roaming male cats and for FeLV, younger, free -roaming cats.
Accuracy of polymerase chain reaction assays for diagnosis of feline immunodeficiency virus infection in cats.
PCR assays used for diagnosis of FIV infection presently marketed to veterinary practitioners in North America vary significantly in diagnostic accuracy and did not resolve the diagnostic dilemma resulting from vaccination of cats against FIV.
Lymphoid activation: a confounding factor in AIDS vaccine development?
In the present DNA vaccination trial, although designed so as to minimize non-specific polyclonal activation, immune-mediated enhancement was nonetheless observed in certain immunized cats, and rapid virus dissemination in vivo was associated with the presence of T-helper responses prior to challenge, and was linked to increased susceptibility of lymphocytes to ex vivo infection.
Feline immunodeficiency virus subtypes A, B and C and intersubtype recombinants in Ontario
  • Canada. Journal of General Virology
  • 2004