Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.

@article{Urban2012LimitedCO,
  title={Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.},
  author={Thomas J. Urban and Yufeng Shen and Andrew Stolz and Naga Chalasani and Robert J Fontana and James Rochon and Dongliang Ge and Kevin V. Shianna and Ann K Daly and Maria Isabel Lucena and Matthew R. Nelson and Mariam Molokhia and Guruprasad P Aithal and Aris Floratos and Itsik Pe'er and Jose Salvador Serrano and Herbert L. Bonkovsky and Timothy J. Davern and William M. Lee and Victor J. Navarro and Jayant Talwalkar and David K. Goldstein and Paul B Watkins},
  journal={Pharmacogenetics and genomics},
  year={2012},
  volume={22 11},
  pages={784-95}
}
BACKGROUND AND AIMS Drug-induced liver injury (DILI) is a serious adverse drug event that is suspected to have a heritable component. We carried out a genome-wide association study of 783 individuals of European ancestry who experienced DILI due to more than 200 implicated drugs. METHODS DILI patients from the US-based Drug-Induced Liver Injury Network (n=401) and three international registries (n=382) were genotyped with the Illumina 1Mduo BeadChip and compared with population controls (n… CONTINUE READING

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