Limited central side effects of a β-subunit subtype-selective GABAA receptor allosteric modulator

@article{Yoshimura2014LimitedCS,
  title={Limited central side effects of a $\beta$-subunit subtype-selective GABAA receptor allosteric modulator},
  author={Ryan F. Yoshimura and Minhtam B. Tran and Derk J. Hogenkamp and Timothy B C Johnstone and Jennifer Xie and Frank Porreca and Kelvin W. Gee},
  journal={Journal of Psychopharmacology},
  year={2014},
  volume={28},
  pages={472 - 478}
}
GABAergic anxiolytics have well-documented centrally mediated side effects including sedation, potentiation of ethanol, tolerance, abuse liability and memory impairment. Most research directed towards identifying an anxioselective GABAergic therapeutic has been based upon the theory that these side effects could be mitigated by avoiding α1/5-subunit GABAA receptors while specifically targeting those with the α2/3-subunit. Unfortunately, there are prominent exceptions to this theory and it has… 

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