Limited Efficacy of α-Conopeptides, Vc1.1 and RgIA, To Inhibit Sensory Neuron CaV Current1,2,3

@inproceedings{Wright2015LimitedEO,
  title={Limited Efficacy of α-Conopeptides, Vc1.1 and RgIA, To Inhibit Sensory Neuron CaV Current1,2,3},
  author={Andrew B. Wright and Yohei Norimatsu and John McIntosh and Keith S. Elmslie},
  booktitle={eNeuro},
  year={2015}
}
Chronic pain is very difficult to treat. Thus, novel analgesics are a critical area of research. Strong pre-clinical evidence supports the analgesic effects of α-conopeptides, Vc1.1 and RgIA, which block α9α10 nicotinic acetylcholine receptors (nAChRs). However, the analgesic mechanism is controversial. Some evidence supports the block of α9α10 nAChRs as an… CONTINUE READING