Limited Contribution of DNA Methylation Variation to Expression Regulation in Arabidopsis thaliana

@inproceedings{Meng2016LimitedCO,
  title={Limited Contribution of DNA Methylation Variation to Expression Regulation in Arabidopsis thaliana},
  author={Dazhe Meng and Manu Jody Dubin and Pei Zhang and Edward J. Osborne and Oliver Stegle and Richard M. Clark and Magnus Nordborg},
  booktitle={PLoS genetics},
  year={2016}
}
The extent to which epigenetic variation affects complex traits in natural populations is not known. We addressed this question using transcriptome and DNA methylation data from a sample of 135 sequenced A. thaliana accessions. Across individuals, expression was significantly associated with cis-methylation for hundreds of genes, and many of these associations remained significant after taking SNP effects into account. The pattern of correlations differed markedly between gene body methylation… CONTINUE READING
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DNAmethylation variation in Arabidopsis has a genetic basis and appears to be involved in local adaptation

  • MJ Dubin, P Zhang, D Meng, MS Remigereau, EJ Osborne, FP Casale
  • eLife
  • 2015
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