Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys.

@article{Chan2010LimitedCT,
  title={Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys.},
  author={Ming Liang Chan and Janka Petravic and Alexandra M Ortiz and Jessica C. Engram and Mirko Paiardini and Deborah Cromer and Guido Silvestri and Miles P. Davenport},
  journal={Proceedings. Biological sciences},
  year={2010},
  volume={277 1701},
  pages={
          3773-81
        }
}
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections result in chronic virus replication and progressive depletion of CD4+ T cells, leading to immunodeficiency and death. In contrast, 'natural hosts' of SIV experience persistent infection with high virus replication but no severe CD4+ T cell depletion, and remain AIDS-free. One important difference between pathogenic and non-pathogenic infections is the level of activation and proliferation of CD4+ T cells. We… CONTINUE READING

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