Limitations of tissue microarrays in the evaluation of focal alterations of bcl-2 and p53 in whole mount derived prostate tissues.

@article{Merseburger2003LimitationsOT,
  title={Limitations of tissue microarrays in the evaluation of focal alterations of bcl-2 and p53 in whole mount derived prostate tissues.},
  author={Axel Stuart Merseburger and Markus Antonius Kuczyk and Jurgen Serth and Carsten Bokemeyer and Denise Y. Young and Leon Sun and Roger R Connelly and David G. Mcleod and Fathollah K. Mostofi and Shiv K. Srivastava and Arnulf Stenzl and Judd W. Moul and Isabell A. Sesterhenn},
  journal={Oncology reports},
  year={2003},
  volume={10 1},
  pages={
          223-8
        }
}
Several investigators have reported the correlation of p53 and bcl-2 immunoreactivity with post operative prostate specific antigen (PSA) recurrence. Focal and or clustered expression is typical for these biomarkers. The purpose of this study was to compare the effectiveness of tissue microarrays to detect p53 and bcl-2 overexpression and their prognostic significance. Tissue microarrays (TMA) of 99 patients with mean follow-up of 61 months contained 760 samples from 241 carcinomas, 431 benign… CONTINUE READING

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