Limitations of tissue microarrays compared with whole tissue sections in survival analysis.

@article{Khouja2010LimitationsOT,
  title={Limitations of tissue microarrays compared with whole tissue sections in survival analysis.},
  author={M Haysam Khouja and Mark M O Baekelandt and Agkha Sarab and Jahn Marthin Nesland and Ruth Holm},
  journal={Oncology letters},
  year={2010},
  volume={1 5},
  pages={827-831}
}
Tissue microarray (TMA) is a promising technique in the evaluation of immunohistochemical markers in tumors and may be used as an alternative for whole sections. However, only a few studies have correlated a clinical outcome with both TMA and results obtained from whole sections. This study compared immunostaining for Ki-67 and p16 in TMA (3 cores from each specimen) and whole sections of 171 cases of stage III epithelial ovarian cancer with clinical data. A high expression of Ki-67 was… CONTINUE READING