Limitations of the maximum entropy principle in devising drug input rate

Abstract

A computer program applying the principle of maximum entropy to the analysis of drug absorption rate has been developed. Plasma concentrations of amoxicillin obtained after oral and intravenous dosing have been analysed, together with simulated data corresponding to a complex input. Amoxicillin absorption rates devised by the program were similar to those… (More)
DOI: 10.1007/BF00192372

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