Limitations of dynamic contrast-enhanced MRI in monitoring radiation-induced changes in the fraction of radiobiologically hypoxic cells in human melanoma xenografts.

Abstract

PURPOSE To investigate the potential of gadopentetate dimeglumine (Gd-DTPA)-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in detecting radiation-induced changes in the fraction of radiobiologically hypoxic cells in A-07 human melanoma xenografts. MATERIALS AND METHODS A-07 tumors were randomly assigned to an unirradiated control… (More)
DOI: 10.1002/jmri.21602

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