Limitations of adaptive clinical trials.

  • M. -A. Buyse
  • Published 2012 in
    American Society of Clinical Oncology educational…


Adaptive designs are aimed at introducing flexibility in clinical research by allowing important characteristics of a trial to be adapted during the course of the trial based on data coming from the trial itself. Adaptive designs can be used in all phases of clinical research, from phase I to phase III. They tend to be especially useful in early development… (More)
DOI: 10.14694/EdBook_AM.2012.32.133