Limitations of a molecular clock applied to considerations of the origin of HIV-1.

  title={Limitations of a molecular clock applied to considerations of the origin of HIV-1.},
  author={Bette T Korber and James Theiler and Steven Wolinsky},
  volume={280 5371},
The evolutionary history of human immunodeficiency virus (HIV) is unfolding even as we study it, a consequence of the underlying genetic variation by mutation (1), recombination (2, 3), and frequent insertions and deletions (4). Studies of the evolutionary history of HIV enable us to extrapolate into the past and make estimates of the age of the epidemic, as well as make predictions of the potential for variation in the future that will affect vaccine development. The HIV-1 main (M) group… CONTINUE READING
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