Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease

@article{Kuntner2009LimitationsOS,
  title={Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease},
  author={Claudia Kuntner and Adam Leon Kesner and Martin Peter Bauer and Robert Kremslehner and Thomas Wanek and Markus Mandler and Rudolf Karch and Johann Stanek and Tanja Wolf and Markus M{\"u}ller and Oliver Langer},
  journal={Molecular Imaging and Biology},
  year={2009},
  volume={11},
  pages={236-240}
}
We evaluated the usefulness of small animal brain positron emission tomography (PET) imaging with the amyloid-beta (Aβ) probe 2-(1-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malonitrile ([18F]FDDNP) and with 2-deoxy-2-[F-18]fluoro-d-glucose (FDG) for detection and quantification of pathological changes occurring in a transgenic mouse model of Alzheimer’s disease (Tg2576 mice). [18F]FDDNP (n = 6) and FDG-PET scans (n = 3) were recorded in Tg2576 mice (age 13–15 months) and age… CONTINUE READING

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