Limitations in using peptide drugs to characterize calcitonin gene-related peptide receptors.

@article{Waugh1999LimitationsIU,
  title={Limitations in using peptide drugs to characterize calcitonin gene-related peptide receptors.},
  author={David T. Waugh and Charles S. Bockman and Daryl D. Smith and Peter W. Abel},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={289 3},
  pages={
          1419-26
        }
}
Calcitonin gene-related peptide (CGRP) is an endogenous vasodilator peptide that produces its effects by activation of CGRP1 and CGRP2 receptor subtypes. These receptor subtypes are characterized in functional studies using the agonist Cys(Acm)2, 7-human-alpha-calcitonin gene-related peptide (Cys(ACM)2, 7-h-alpha-CGRP), which activates CGRP2 receptors, and the antagonist h-alphaCGRP(8-37) which has a high affinity for CGRP1 receptors and a low affinity for CGRP2 receptors. Our aim was to… CONTINUE READING

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