Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning.

Abstract

Acetylcholinesterase (AChE; EC 3.1.1.7), an essential enzyme of cholinergic neurotransmission in vertebrates, is a primary target in acute nerve agent and organophosphate (OP) pesticide intoxication. Catalytically inactive OP-AChE conjugates formed between the active-center serine and phosphorus of OPs can, in principle, be reactivated by nucleophilic oxime… (More)
DOI: 10.1111/nyas.13128

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