Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons

@article{Dietrich2012LimitationsIA,
  title={Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons},
  author={Marcelo de Oliveira Dietrich and Tam{\'a}s L. Horv{\'a}th},
  journal={Nature Reviews Drug Discovery},
  year={2012},
  volume={11},
  pages={675-691}
}
Current anti-obesity drugs aim to reduce food intake by either curbing appetite or suppressing the craving for food. However, many of these agents have been associated with severe psychiatric and/or cardiovascular side effects, highlighting the need for alternative therapeutic strategies. Emerging knowledge on the role of the hypothalamus in enabling the central nervous system to adapt to the changing environment — by managing peripheral tissue output and by regulating higher brain functions… CONTINUE READING