Limitation on the use of amiloride in early renal failure

  title={Limitation on the use of amiloride in early renal failure},
  author={H. Knauf and K. Reuter and E. Mutschler},
  journal={European Journal of Clinical Pharmacology},
SummaryThe effect of a single oral dose of 10 mg amiloride was studied on urinary excretion of Na+, K+, Ca++ and Mg++ in healthy subjects and in patients with varying degrees of renal impairment. Amiloride produced a moderate diuresis and sodium excretion, and a slight calciuresis. Urinary excretion of potassium was significantly reduced as compared to the controls. Despite its diuretic and natriuretic effects, amiloride did not change the excretion of Mg++ as compared to the pretreatment… Expand
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