Limitation of myocardial function by reduced coronary blood flow during isoproterenol action.


The interpolated decrease in heart force or isometric systolic tension that occurs during isoproterenol stimulation has been examined in terms of changes in coronary flow and myocardial metabolism. In 67 open-chest dogs under pentobarbital anesthesia, determinations were made of lactate, pyruvate, Po2 and Pco2 in arterial and coronary sinus blood; coronary… (More)


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