Limitation of exercise capacity in nucleoside-treated HIV-infected patients with hyperlactataemia.

@article{Duong2007LimitationOE,
  title={Limitation of exercise capacity in nucleoside-treated HIV-infected patients with hyperlactataemia.},
  author={Michel Duong and J. P. Dumas and Marielle Buisson and Beno{\^i}t Martha and Lionel Piroth and Mich{\'e}le Grappin and Anne Waldner and Pascal Chavanet and Henri Portier},
  journal={HIV medicine},
  year={2007},
  volume={8 2},
  pages={105-11}
}
BACKGROUND Inhibition of DNA polymerase gamma by nucleoside reverse transcriptase inhibitors (NRTIs) can cause mitochondrial dysfunction and cellular toxicity. Hyperlactataemia, which is a consequence of a shift in the metabolism of pyruvate, is an indicator of nucleoside-related mitochondrial toxicity. METHODS We evaluated exercise and oxidative… CONTINUE READING