Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora.

@article{Leloup1999LimitCM,
  title={Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora.},
  author={Juliette Leloup and Didier Gonze and Albert Goldbeter},
  journal={Journal of biological rhythms},
  year={1999},
  volume={14 6},
  pages={
          433-48
        }
}
We examine theoretical models for circadian oscillations based on transcriptional regulation in Drosophila and Neurospora. For Drosophila, the molecular model is based on the negative feedback exerted on the expression of the per and tim genes by the complex formed between the PER and TIM proteins. For Neurospora, similarly, the model relies on the feedback exerted on the expression of the frq gene by its protein product FRQ. In both models, sustained rhythmic variations in protein and mRNA… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Assign - mentof circadianfunctionfor the Neurospora clockgene frequency

T Pavlidis
  • Nature
  • 1999

TheGoodwinmodel : Simulatingtheeffectof cycloheximideandheatshockonthesporulationrhythmof Neurospora crassa

JE Rutila, V Suri, M Le, RosbashM SoWV, JC andHall
  • J Theor Biol
  • 1999

A modelfor circadian rhythmsin Drosophila incorporatingthe formationof a complex betweenthe PER and TIM proteins

LeloupJ-CandGoldbeterA
  • J Biol Rhythms
  • 1998

A mutantDrosophilahomologof mammalianclockdisruptscircadianrhythmsandtranscriptionof periodand timeless

AlladaR, WhiteNE, SoWV, JC Hall, andRosbashM
  • Cell
  • 1998

CYCLE is a secondbHLH-PAS clock protein essentialfor circadianrhythmicity andtranscriptionof Drosophila periodandtimeless

JE Rutila, V Suri, +3 authors JC andHall
  • Cell
  • 1998

Choline depletion , frq mutations , andtemperaturecompensationof thecircadianrhythm in Neurospora crassa

LeloupJ-CandGoldbeterA
  • J Biol Rhythms
  • 1998

Closingthe circadianloop : CLOCKinduced transcriptionof its own inhibitors per and tim

TK Darlington, Wager-SmithK, +4 authors SA andKay
  • Science
  • 1998

Commonthreadsin eukaryoticcircadian systems

ZwiebelLJ EderyI, DembinskaME
  • Curr Opin Genet Dev
  • 1998

Drosophila photoreceptors containanautonomouscircadianoscillatorthatcanfunctionwithout period mRNAcycling

PE ChengYandHardin
  • JNeurosci
  • 1998

Nuclearlocalizationis requiredfor functionof theessentialclockproteinFRQ

M Merrow
  • EMBO J
  • 1998