Limit Cycle Models for Circadian Rhythms Based on Transcriptional Regulation in Drosophila and Neurospora

@article{Leloup1999LimitCM,
  title={Limit Cycle Models for Circadian Rhythms Based on Transcriptional Regulation in Drosophila and Neurospora},
  author={Jean-Christophe Leloup and Didier Gonze and Albert Goldbeter},
  journal={Journal of Biological Rhythms},
  year={1999},
  volume={14},
  pages={433 - 448}
}
We examine theoretical models for circadian oscillations based on transcriptional regulation in Drosophila and Neurospora. For Drosophila, the molecular model is based on the negative feedback exerted on the expression of the per and tim genes by the complex formed between the PER and TIM proteins. For Neurospora, similarly, the model relies on the feedback exerted on the expression of the frq gene by its protein product FRQ. In both models, sustained rhythmic variations in protein and mRNA… Expand
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