Lime

Abstract

Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck-interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after crosslinking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family… (More)

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