Limbic encephalitis as a relapse of Whipple’s disease with digestive involvement and spondylodiscitis

@article{Brnnimann2018LimbicEA,
  title={Limbic encephalitis as a relapse of Whipple’s disease with digestive involvement and spondylodiscitis},
  author={Didier Br{\"o}nnimann and Marc-Olivier Vareil and I. Obreg{\'o}n Sib{\'o}n and Jean-Christophe Lagier and Hubert L{\'e}pidi and Mathilde Pug{\`e}s and Fatiha Han{\`e}che and Didier Raoult and Arnaud Desclaux and Didier Neau and Charles Cazanave},
  journal={Infection},
  year={2018},
  pages={1-5}
}
IntroductionMany clinical manifestations can be related to Tropheryma whipplei infection.Case reportWe report a Tropheryma whipplei limbic encephalitis developed as a relapse of classical Whipple’s disease.DiscussionThis case is to the best of our knowledge the first proof of the effective brain–blood barrier crossing of both doxycycline and hydroxychloroquine as demonstrated by direct concentration monitoring on brain biopsy. 
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