Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study

@article{Franklin2007LimbicAT,
  title={Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study},
  author={Teresa R. Franklin and Ze Wang and Jiongjiong Wang and Nathan Sciortino and Derek Harper and Yin Li and Ron Ehrman and Kyle M. Kampman and Charles P O'brien and John A. Detre and Anna Rose Childress},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={2301-2309}
}
Exposure to cigarette smoking cues can trigger physiological arousal and desire to smoke. The brain substrates of smoking cue-induced craving (CIC) are beginning to be elucidated; however, it has been difficult to study this state independent of the potential contributions of pharmacological withdrawal from nicotine. Pharmacological withdrawal itself may have substantial effects on brain activation to cues, either by obscuring or enhancing it, and as CIC is not reduced by nicotine replacement… CONTINUE READING
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