Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia.

@article{Freeman2002LimbVC,
  title={Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia.},
  author={Roy Freeman and Vasilios Lirofonis and William B. Farquhar and Marcelo Risk},
  journal={Journal of applied physiology},
  year={2002},
  volume={93 2},
  pages={
          636-44
        }
}
Venous denervation and increased venous pooling may contribute to symptoms of orthostatic intolerance. We examined venous compliance in the calf and forearm in 11 orthostatic-intolerant patients and 15 age-matched controls over a range of pressures, during basal conditions and sympathetic excitation. Occlusion cuffs placed around the upper arm and thigh were inflated to 60 mmHg and deflated to 10 mmHg over 1 min. Limb volume was measured continuously with a mercury-in-Silastic strain gauge… 
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Citation Type

Microvascular Filtration Is Increased in Postural Tachycardia Syndrome
TLDR
Increased microvascular filtration accounts for enhanced leg swelling in patients with POTS with increased arterial blood flow and was invariant with orthostasis.
Gender affects calf venous compliance at rest and during baroreceptor unloading in humans.
  • K. Monahan, C. Ray
  • Biology, Medicine
    American journal of physiology. Heart and circulatory physiology
  • 2004
TLDR
Data indicate gender-dependent effects on calf venous compliance under conditions associated with low sympathetic outflow and LBNP, but these data cannot explain gender-associated differences in orthostatic tolerance.
Reduced venous compliance: an important determinant for orthostatic intolerance in women with vasovagal syncope.
TLDR
The new VWM accurately adopted the curvilinear pressure-volume curve, providing a valid characterization of venous compliance, and may adversely affect mobilization of peripheral venous blood to the central circulation during hypovolemic circulatory stress in women with VVS.
Local vascular responses affecting blood flow in postural tachycardia syndrome.
TLDR
Local blood flow regulation in low-flow POTS is impaired and the duration of hyperemic blood flow was curtailed in LFP compared with either control or HFP subjects, and reactive hyperemi flow and cutaneous flow were similar in all subjects.
Effects of 18 days of bed rest on leg and arm venous properties.
TLDR
It is demonstrated that after bed rest, leg venous compliance is reduced and legs venous outflow resistance is enhanced; however, these changes are not related to measures of orthostatic tolerance; therefore, alterations in venous Compliance do not to play a major role in orthostatics intolerance after 18 days of head-down tilt bed rest.
Venous smooth muscle tone and responsiveness in older adults.
TLDR
Data suggest that forearm and calf venous compliance is lower in older adults compared with young, however, this difference probably cannot be explained by alterations in smooth muscle tone or responsiveness.
Limb venous tone and responsiveness in hypertensive humans.
TLDR
While venous compliance was similar between NTN and HTN adults,HTN adults have lower forearm venous capacitance (volume) which is increased with NTG, and data suggest that young HTn adults may have augmented venous smooth muscle tone compared with NTN controls.
Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome.
TLDR
It is suggested that POTS patients have exaggerated MSNA responses to baroreflex challenges compared with healthy control subjects, although resting supine MSNA values did not differ between the groups.
Decreased compliance in the deep and superficial conduit veins of the upper arm during prolonged cycling exercise
TLDR
It is suggested that CPL in the deep and superficial conduit veins adjusts to prolonged exercise via different mechanisms.
Alterations of calf venous and arterial compliance following acclimation to heat administered at a fixed daily time in humans
TLDR
It is suggested that repeated heat exposure in humans, for 4 h at a fixed time daily, increases the calf CV and the CSA particularly during the period when the subjects were previously exposed to heat.
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